AQA GCSE Combined Science Trilogy · 8464
Specification 4.2.2.1, 4.4.1.2 · Paper 1
A change in an enzyme's shape that prevents its active site from binding its substrate effectively.
Revise: Enzyme action and investigating pHFewer enzyme–substrate complexes can form, so the reaction rate falls. This change is called denaturation.
- Revise: Limiting Factors and Greenhouse Conditions
A change in an enzyme’s shape, including its active site, so that its substrate no longer fits and the enzyme cannot catalyse the reaction effectively.