Denaturation

A change to a protein’s three-dimensional shape, including its active site, so that it can no longer perform its normal function.

The permanent change in an enzyme's shape at high temperature, including a change to its active site.

A change in an enzyme’s three-dimensional shape, including its active site, that prevents it from functioning properly.

A change in an enzyme’s shape that prevents it from working effectively.

A change in an enzyme’s shape, including its active site, so its substrate no longer fits properly.

The permanent change in an enzyme's three-dimensional shape at high temperature, including a change to its active site.

The loss of an enzyme's specific three-dimensional shape, so its active site can no longer function effectively.

A permanent change to an enzyme's active site so that its substrate no longer fits.

A permanent change in a protein enzyme's shape so that its active site is no longer complementary to its substrate.