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GCSE Biology · key term
Having shapes that fit together, as the normal active site and its substrate do.
Used by Edexcel
Specification 1.8 · Paper 1, Paper 2
Revise: DenaturationThe active site has a shape and chemical environment complementary to a particular substrate, allowing the substrate to bind and form an enzyme–substrate complex.
Use the sequence: conditions disrupt bonds or other interactions → the enzyme’s three-dimensional shape changes → the active site changes shape → the substrate is no longer complementary → fewer or no enzyme–substrate complexes form.
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