Denatured

Definition

Permanently changed in shape so that an enzyme's active site is no longer complementary to its substrate.

Used by Edexcel and OCR

Specification 1.9 · Paper 1, Paper 2

The reaction is slow, but the enzyme is not usually denatured: warming it can increase its activity again.
Revise: Factors Affecting Enzyme Activity

Specification B1.2g · Paper 1 (Foundation), Paper 3 (Higher)

A permanent change in an enzyme's three-dimensional shape so that its active site is no longer complementary to its substrate.

1
Do not say that an enzyme is killed. At high temperatures or unsuitable pH values, it is denatured because its active site changes shape.
2
Do not say that an enzyme “dies”. At high temperatures or extreme pH, it is denatured; low temperature usually only slows its activity.

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The enzyme has been denatured, a permanent structural change.